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Related Experiment Video

Updated: Jan 29, 2026

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Published on: May 18, 2016

Human African Trypanosomiasis: Progress and Stagnation.

Emmanuel Bottieau¹, Jan Clerinx¹

¹Department of Clinical Sciences, Institute of Tropical Medicine, Nationalestraat 155, Antwerpen 2000, Belgium.

Infectious Disease Clinics of North America

|February 5, 2019

Summary

This summary is machine-generated.

Control efforts have reduced human African trypanosomiasis (HAT) prevalence. While gambiense HAT management has improved, rhodesiense HAT treatment remains a challenge, impacting travelers.

Keywords:

Clinical presentation Diagnosis Human African trypanosomiasis Treatment Trypanosoma brucei gambiense Trypanosoma brucei rhodesiense

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Area of Science:

Neglected tropical diseases
Parasitology
Public health

Background:

Human African trypanosomiasis (HAT) is a vector-borne parasitic disease.
Control efforts have decreased HAT prevalence in West/Central and East Africa.
Trypanosoma brucei gambiense causes West African HAT, while T. brucei rhodesiense causes East African HAT.

Purpose of the Study:

To review the current status of HAT control and treatment.
To highlight recent advancements in managing T. brucei gambiense HAT.
To identify the lack of progress in treating T. brucei rhodesiense HAT.

Main Methods:

Review of recent literature on HAT.
Analysis of control strategies and treatment advancements.
Comparison of management approaches for T. brucei gambiense and T. brucei rhodesiense.

Main Results:

Significant reduction in HAT prevalence due to control efforts.
Improved diagnostics and treatments (nifurtimox-eflornithine, fexinidazole) for T. brucei gambiense HAT.
Lack of significant therapeutic advances for T. brucei rhodesiense HAT.

Conclusions:

T. brucei gambiense HAT management has seen substantial progress.
T. brucei rhodesiense HAT, a zoonosis affecting travelers, lacks comparable treatment advancements.
Further research is needed for effective T. brucei rhodesiense HAT therapies.