[Treg influences the pathogenesis of allergic rhinitis through TICAM-1 pathway]

Allergic rhinitis is an immunoglobulin E (IgE)-mediated type I allergic disorder of the nasal mucosa, which is caused by an imbalance in the cytokine network, a number of intracellular signaling pathways being actived. Treg is known to have immunosuppressive effects. Numerous studies have shown that Toll-like receptors play an important immunomodulatory role in the pathogenesis of allergic rhinitis, and TICAM-1, as an important adaptor protein in the Toll-like receptor domain, is involved in signal transduction of allergic rhinitis. This article reviews Treg's impact on the pathogenesis of allergic rhinitis through the TICAM-1 pathway to further understand the role of allergic rhinitis in the pathogenesis and to provide new ideas for therapeutic goals for allergic rhinitis.