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Related Concept Videos

Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

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Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
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ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
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Hormonal Regulation01:40

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Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
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Anatomy of the Heart01:27

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The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
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The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
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The status of a reversible reaction is conveniently assessed by evaluating its reaction quotient (Q). For a reversible reaction described by m A + n B ⇌ x C + y D, the reaction quotient is derived directly from the stoichiometry of the balanced equation as
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Related Experiment Video

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Translational Rabbit Model of Chronic Cardiac Pacing
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Left Ventricular Endocardial Pacing/Leadless Pacing.

Alan Hanley1, E Kevin Heist1

  • 1Cardiac Arrhythmia Service, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Cardiac Electrophysiology Clinics
|February 6, 2019
PubMed
Summary
This summary is machine-generated.

Left ventricular endocardial pacing offers a promising alternative to traditional cardiac resynchronization therapy, overcoming challenges and potentially improving patient outcomes in heart failure.

Keywords:
CRTHeart failureLV endocardial pacingWiSE-CRT

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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Research

Background:

  • Cardiac resynchronization therapy (CRT) is established for heart failure with impaired left ventricular function and dyssynchrony.
  • Traditional CRT faces challenges like coronary sinus anatomy limitations and non-response.
  • Left ventricular (LV) endocardial pacing presents an alternative approach.

Purpose of the Study:

  • To evaluate the potential of LV endocardial pacing as an alternative to traditional CRT.
  • To explore overcoming limitations of transvenous CRT systems.
  • To assess the hemodynamic and remodeling effects of LV endocardial pacing.

Main Methods:

  • Review of existing case studies and series demonstrating LV endocardial pacing.
  • Analysis of preclinical studies on hemodynamic effects.
  • Discussion of recent innovations in leadless LV endocardial pacing technology.

Main Results:

  • LV endocardial pacing may overcome anatomic constraints and allow for more physiologic activation.
  • Preclinical data suggest superior hemodynamic effects compared to traditional methods.
  • Early clinical data and case series indicate promise for the approach.

Conclusions:

  • LV endocardial pacing shows potential to improve CRT delivery and patient response.
  • Leadless LV endocardial pacing is an emerging innovation undergoing testing.
  • Successful LV endocardial pacing may lead to clinical benefits and positive cardiac remodeling.