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Contemporary Treatment of Heart Failure

Maya H Barghash1, Sean P Pinney1

  • 1Department of Medicine, Division of Cardiology, Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.

Cardiac Electrophysiology Clinics
|February 6, 2019
PubMed

Insights

Heart failure (HF) impacts millions, incurring substantial costs. Advanced treatments like left ventricular assist devices and cardiac transplantation offer improved survival and quality of life for end-stage heart failure patients.

Area of Science:

  • Cardiology
  • Medical Devices
  • Transplantation

Background:

  • Heart failure (HF) affects 2.4% of US adults, posing significant healthcare burdens.
  • Medical and device therapies improve outcomes for HF with reduced ejection fraction.
  • Stage D HF involves severe limitations, frequent hospitalizations, and intolerance to standard treatments.

Purpose of the Study:

  • To highlight the characteristics and advanced treatment options for Stage D heart failure.
  • To emphasize the importance of early referral for advanced therapies.

Main Methods:

  • Review of current medical and device therapies for heart failure.
  • Analysis of outcomes associated with left ventricular assist devices and cardiac transplantation.
  • Discussion of patient selection criteria for advanced therapies.

Main Results:

  • Advanced therapies, including left ventricular assist devices and cardiac transplantation, reduce mortality.
  • These interventions also improve the quality of life for patients with end-stage heart failure.
  • Early referral to specialized centers is crucial for successful patient selection and treatment.

Conclusions:

  • Stage D heart failure necessitates consideration of advanced therapies.
  • Left ventricular assist devices and cardiac transplantation are vital for improving survival and quality of life.
  • Timely referral to expert centers optimizes outcomes for advanced heart failure management.

Keywords:
Advanced heart failureCardiac transplantationDevice therapy in heart failureHeart failure with reduced ejection fraction (HFrEF)Mechanical circulatory supportPharmacotherapy in heart failureStage D heart failure

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