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Minocycline-induced transient depersonalization: A case report
Yassein Shamout1, Alissa Sigal2, Ivan V Litvinov1
1Division of Dermatology, McGill University, Montreal, QC, Canada.
SAGE Open Medical Case Reports
|February 6, 2019
Summary
Minocycline, used for acne, can rarely cause depersonalization. This case highlights a potential severe central nervous system side effect requiring clinical recognition.
Area of Science:
- Neurology
- Dermatology
- Psychiatry
Background:
- Minocycline is a widely prescribed antibiotic for acne vulgaris.
- Known central nervous system side effects include headaches and vestibular dysfunction.
- Depersonalization as a side effect is infrequently reported.
Observation:
- A 37-year-old female with perioral dermatitis developed severe depersonalization within one week of minocycline treatment.
- This case highlights a rare but significant adverse event associated with minocycline therapy.
Findings:
- The exact mechanism of minocycline-induced depersonalization remains unclear.
- Hypotheses include serotonin system hypersensitivity, metabolic encephalopathy, and panic-disorder etiology.
Implications:
- Depersonalization is a potentially severe side effect of minocycline.
- Clinicians should be aware of this adverse event for prompt diagnosis and management.
- Further research is needed to elucidate the underlying pathophysiology.
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