Acceleration of Double Inversion Recovery Sequences in Multiple Sclerosis With Compressed Sensing

Area of Science:

• Radiology
• Medical Imaging
• Neuroimaging

Background:

• Double inversion recovery (DIR) is crucial for detecting multiple sclerosis (MS) lesions.
• Accelerated imaging techniques are needed to improve clinical workflow efficiency.

Purpose of the Study:

• To evaluate the performance of compressed sensing (CS) accelerated DIR sequences in a clinical setting for MS.
• To compare the diagnostic quality and artifact profile of CS-DIR versus conventional SENSE-accelerated DIR.

Main Methods:

• A prospective study included 106 MS patients.
• Acquired both conventional SENSE-accelerated DIR and CS-accelerated DIR (51% time reduction).
• Two neuroradiologists assessed subtraction maps for lesions and artifacts, comparing counts and agreement using ICC.

Main Results:

• CS-DIR detected all definite lesions identified by conventional DIR.
• No significant difference in the number of possible lesions detected between the two sequences (P=0.57).
• Conventional DIR showed significantly more white matter (P=0.024) and cortical-sulcal interface (P<0.001) artifacts. ICC was near perfect (0.985 and 0.981).

Conclusions:

• Compressed sensing accelerates DIR sequences substantially without compromising diagnostic quality for MS.
• CS-accelerated DIR demonstrates improved performance with significantly fewer artifacts compared to conventional DIR.