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Feeding during transfusion and the risk of necrotizing enterocolitis in preterm infants

Monika Bajaj1, Mirjana Lulic-Botica2, Amber Hanson2

  • 1Carman and Ann Department of Pediatrics, Department of Pediatrics, Hutzel Women's Hospital, 3980 John R Rd, Detroit, MI, 48201, USA. mbajaj@dmc.org.

Journal of Perinatology : Official Journal of the California Perinatal Association
|February 7, 2019
PubMed

Insights

Withholding feeds during blood transfusions did not significantly decrease transfusion-associated acute gut injury (TRAGI) in preterm infants. Further research is needed to understand the relationship between feeding practices and gut injury during transfusions.

Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Clinical Nutrition

Background:

  • Transfusion-associated acute gut injury (TRAGI) is a serious complication in preterm infants.
  • Current practices for managing TRAGI are not well-established.
  • Investigating feeding strategies during blood transfusions is crucial for infant health.

Purpose of the Study:

  • To assess the impact of withholding enteral feeds during blood transfusions on TRAGI rates in preterm infants.
  • To determine if a 12-24 hour fasting period during transfusion reduces the incidence of TRAGI.
  • To analyze factors associated with TRAGI development.

Main Methods:

  • A retrospective study involving 125 preterm infants.
  • Data collected before and after implementing a policy of withholding feeds during transfusion.
  • Logistic regression analysis used to evaluate the effect of withholding feeds on TRAGI rates.

Main Results:

  • No significant difference in TRAGI rates was observed before and after the implementation of withholding feeds.
  • 15% of infants developed necrotizing enterocolitis (NEC), with 32% of those experiencing TRAGI.
  • Postnatal hydrocortisone use was significantly associated with TRAGI (OR 8.97).

Conclusions:

  • Withholding feeds during blood transfusions did not lead to a significant reduction in TRAGI.
  • The relationship between feeding during transfusion and NEC requires further investigation.
  • Additional studies are warranted to explore optimal feeding strategies during transfusion in preterm neonates.
Abstract

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