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A hydrate salt-promoted reductive coupling reaction of nitrodienes with unactivated alkenes
Mengmeng Zhang1, Liming Yang, Chao Tian
1Key Laboratory of Functional Inorganic Material Chemistry (MOE), School of Chemistry and Materials Science, Heilongjiang University, No. 74, Xuefu Road, Nangang District, Harbin 150080, P. R. China. gmli@hlju.edu.cn chemagh@163.com.
Abstract:
Transition metal-catalyzed reductive coupling has emerged as a powerful method for the construction of C-C bonds. Herein, a crystalline hydrate, Na2HPO4·7H2O, has been disclosed as an effective promoter for the reductive coupling of nitrodienes with unactivated alkenes to afford diverse dienes with various functionalities in an open-flask manner. The mechanism study has revealed that Na2HPO4·7H2O accelerates the in situ generation of active silane PhSi(OEt)H2 and prevents the deactivation of catalyst. The approach can increase the efficiency of previous reductive coupling reactions as well.
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