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Related Experiment Videos

Magnesium and the lungs.

R Mathew1, B M Altura

  • 1Division of Pediatric Cardiology, New York Medical College, Valhalla.

Magnesium
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Magnesium ions (Mg2+) show promise for treating lung diseases like asthma and pulmonary hypertension by regulating airway and vascular tone. Further research is needed to explore Mg salts as potential therapies.

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Area of Science:

  • Pulmonary Medicine
  • Cardiovascular Physiology
  • Biochemistry

Background:

  • Magnesium ions (Mg2+) are increasingly recognized for their role in regulating bronchial and pulmonary vascular smooth muscle tone.
  • Interest is growing in Mg salts for treating lung diseases such as asthma, allergies, and pulmonary hypertension.

Purpose of the Study:

  • To review the evidence for Mg2+ influence on lung physiology and its therapeutic potential in respiratory and pulmonary vascular diseases.
  • To highlight new experimental data on Mg2+ effects on lung structures and chemicals.

Main Methods:

  • Review of existing clinical reports and experimental findings on magnesium's role in lung function.
  • Analysis of Mg2+ effects on bronchial and pulmonary vascular tone, mast cell activity, and mediator release.

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  • Examination of Mg2+ influence on lung structures like endothelial cells and epithelial cells.

    • Main Results:

    • Mg2+ influences bronchial vasomotor tone, pulmonary vascular contractility, and mast cell degranulation.
    • Pulmonary arterial muscle cells exhibit lower Mg2+ content, suggesting potential vascular vulnerability.
    • Mg2+ has shown beneficial effects in asthma and asthma-like conditions and can prevent experimental pulmonary hypertension in rats.
    • Hypoxic pulmonary vasoconstriction is attenuated by Mg2+.

    Conclusions:

    • Mg salts represent a potentially valuable therapeutic approach for asthma and pulmonary hypertension.
    • Further clinical and experimental investigation into Mg2+ 's role in lung diseases is warranted.
    • Dietary Mg2+ deficiency's role in these conditions requires further elucidation.