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[Interactions of antitubercular drugs]
F C Hugues1, N Moore, D Julien
1Service de Médecine interne II, Hôpital Laennec, Paris.
Revue De Pneumologie Clinique
|January 1, 1988
Summary
Antituberculous drugs can interact with many other medications. Rifampicin may reduce the effectiveness or increase toxicity of other drugs, while isoniazid can cause drug accumulation, especially with high doses.
Area of Science:
- Pharmacology
- Drug Interactions
- Tuberculosis Treatment
Context:
- Antituberculous drugs are frequently co-administered with medications for other conditions.
- Understanding drug-drug interactions is crucial for safe and effective patient care.
- Potential interactions involve antituberculous agents with each other and with non-antituberculous drugs.
Purpose:
- To review potential interactions between antituberculous drugs and other commonly prescribed medications.
- To identify clinical implications of these drug interactions for patient management.
- To provide guidance on co-administration of antituberculous therapy.
Summary:
- Rifampicin, a potent enzyme inducer, can decrease plasma levels of various drugs, reducing their efficacy or increasing toxicity.
- Isoniazid acts as an enzyme inhibitor, potentially leading to drug accumulation, particularly with antiepileptics and oral anticoagulants.
- Specific interactions include ethambutol with diazepam and streptomycin with other aminoglycosides, the latter being contraindicated.
Impact:
- Highlights the significant impact of rifampicin on drug metabolism and efficacy.
- Underscores the risk of drug accumulation with isoniazid, necessitating careful monitoring.
- Emphasizes contraindications for certain drug combinations, such as streptomycin with other aminoglycosides, to prevent severe adverse events.