[The level of circulating humanin in patients with ischemic heart disease.]

At present, great interest is caused with evaluation of new markers in blood circulation for the estimation a tissue oxidative metabolism disturbance due to the presence of secondary mitochondrial dysfunction in patients with coronary heart disease. Сoronary heart disease is generally accompanied with a decline in mitochondrial respiration and represents the root cause of metabolic abnormalities in tissues. To gain insight into rate of decline of mitochondrial oxidative metabolism in tissues there were proposed humanin as a new marker. The content of humanin in compare with other markers of energy metabolism in 59 patients with coronary heart disease was studied. In the examined patients, a decrease in the level of humanin up to 250 ng/l was observed when compared with its level of 1110 (800 to 1500) ng/l in healthy individuals. In most of the patients increased level of lactic acid from 1.0 to 2.2 mM accompanied in 45 % cases with elevation of pyruvic acid concentration above 99.1 μM was observed. Also, it was found a significant decrease of homoarginine level down to 1.40 (1.0-2.0) versus 2.3 (1.8-3.1) μM in healthy individuals. We found an inverse correlation between the level of humanin and the age of patients (R = -0.35, p = 0.048). It can be concluded that patients with coronary heart disease are characterized by a lower level of humanin and homoarginine in the blood, as well as an increased content of lactic acid, indicators that are the criteria for inhibiting aerobic pathways and reducing mitochondriogenesis.