[Methods for detection the indicators of metabolism in the oral liquid (a rewiew).]

The search for new ways to diagnose diseases of different etiologies and their introduction into practical health care remains one of the priority areas of modern medicine. Among the known methods for the analysis of biological fluids, a special place is occupied by the methods of express diagnostics of various pathological conditions by markers found in the oral fluid. This article presents a critical review of the latest developments of domestic and foreign researchers (56 sources are analyzed) concerning both existing and widely used devices and those that are at the development stage. The prospects of using oral fluid as a diagnostic medium, as well as various methods for the rapid detction of markers of pathological conditions, are discussed. The main principles, advantages and disadvantages of immunochromatographic tests, electrochemical, microfluidic analysis, isothermal amplification, and devices based on smartphones for express diagnostics of various markers in oral fluid are presented.