Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...

Protein Dynamics in Living Cells

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...

Dynamic Equilibrium

Dynamic Equilibrium

A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mapping and engineering the human cell-cell interactome.

Nature biotechnology·2026

Same author

Conserved Cell Type Signatures Across the Brainstem and Spinal Cord in the Mouse Central Nervous System.

bioRxiv : the preprint server for biology·2026

Same author

Replacement-Based Ageing Interventions for Systemic Rejuvenation: Shaping Longevity Science and Clinical Directions.

Aging cell·2026

Same author

Genoarchitecture and input-output organization of the mouse basal ganglia and thalamic parafascicular nucleus.

Nature neuroscience·2026

Same author

Exercise as a Biological Driver of Skeletal Muscle Regeneration and Repair: Implications for Regenerative Rehabilitation.

American journal of physical medicine & rehabilitation·2026

Same author

Toward actionable interventions in human aging (12th ARDD meeting, 2025).

Aging·2026

Search research articles

Related Experiment Video

Updated: Jan 29, 2026

Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis

Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis

Published on: May 20, 2012

Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling.

Cindy T J van Velthoven¹, Thomas A Rando²

¹Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA.

|February 9, 2019

Summary

Stem cells enter a state of quiescence, a reversible growth arrest, not dormancy but poised potential. Understanding this active restraint is key for tissue repair and regeneration in aged or diseased conditions.

More Related Videos

Construction of a Multilayered Mesenchymal Stem Cell Sheet with a 3D Dynamic Culture System

Construction of a Multilayered Mesenchymal Stem Cell Sheet with a 3D Dynamic Culture System

Published on: October 20, 2018

Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress

Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress

Published on: October 13, 2019

Related Experiment Videos

Last Updated: Jan 29, 2026

Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis

Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis

Published on: May 20, 2012

Construction of a Multilayered Mesenchymal Stem Cell Sheet with a 3D Dynamic Culture System

Construction of a Multilayered Mesenchymal Stem Cell Sheet with a 3D Dynamic Culture System

Published on: October 20, 2018

Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress

Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress

Published on: October 13, 2019

Area of Science:

Stem cell biology
Cellular quiescence
Regenerative medicine

Background:

Stem cells can enter a prolonged state of reversible growth arrest, known as quiescence.
Quiescence was traditionally viewed as a dormant state, but emerging evidence highlights it as a state of poised potential and active regulation.

Purpose of the Study:

To review recent advances in understanding stem cell quiescence.
To discuss techniques for analyzing quiescence in vivo.
To explore the implications of quiescence for tissue maintenance and repair.

Main Methods:

Review of current literature on stem cell quiescence.
Discussion of analytical techniques for studying quiescent stem cells in vivo.

Main Results:

Quiescence is an active, regulated state, not simple dormancy.
Understanding quiescent stem cell dynamics offers new therapeutic avenues.
Refined analytical techniques allow deeper insights into in vivo quiescence.

Conclusions:

Stem cell quiescence is a dynamic, poised state crucial for tissue homeostasis.
Advances in understanding and analyzing quiescence are vital for regenerative medicine.
Targeting quiescent stem cells holds promise for treating age-related and degenerative diseases.