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Updated: Jan 29, 2026
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Data Acquisition Protocol for Determining Embedded Sensitivity Functions
Published on: April 20, 2016
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Comparing two visualization protocols for tomosynthesis in screening: specificity and sensitivity of slabs versus
Valentina Iotti1, Paolo Giorgi Rossi2, Andrea Nitrosi3
1Radiology Unit, AUSL Reggio Emilia, IRCCS, Reggio Emilia, Italy. valentina.iotti@ausl.re.it.
European Radiology
|February 10, 2019
Summary
A simplified digital breast tomosynthesis (DBT) protocol reduces reading time and false positives. However, this streamlined approach may decrease sensitivity in cancer detection compared to standard protocols.
Area of Science:
- Radiology
- Medical Imaging
- Oncology
Background:
- Digital breast tomosynthesis (DBT) offers higher sensitivity than digital mammography for breast cancer screening.
- Increased reading time associated with DBT can potentially limit its widespread adoption due to radiologist workload concerns.
Purpose of the Study:
- To compare the accuracy and reading times of a simplified DBT protocol (1-cm-thick slabs) against a standard protocol (slabs + 1-mm-spaced planes).
- Both protocols were integrated with synthetic 2D imaging.
Main Methods:
- Retrospective analysis of 894 DBT examinations from the RETomo trial.
- Two radiologists evaluated DBTs using both simplified and standard protocols, with a 3-month washout period between readings.
- Sensitivity and specificity were assessed using a set of 28 confirmed cancers and 276 negative examinations.
Main Results:
- The simplified protocol showed a sensitivity of 82.8% compared to 90.6% for the standard protocol.
- Specificity was higher with the simplified protocol (97.9%) versus the standard protocol (96.3%).
- Median reading times were 20% to 30% shorter with the simplified protocol, and inter-reader agreement was better (0.68 vs. 0.54).
Conclusions:
- A simplified DBT protocol can significantly reduce reading time and the number of false positives.
- While beneficial for efficiency, the simplified protocol may lead to a reduction in cancer detection sensitivity.
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