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Related Experiment Video

Updated: Jan 29, 2026

Technique to Target Microinjection to the Developing Xenopus Kidney

Technique to Target Microinjection to the Developing Xenopus Kidney

Published on: May 3, 2016

Methods of Computational Analysis in Kidney Development.

Pauli Tikka¹, Franz Schaefer²

¹Department of Medicine, University of Heidelberg, Heidelberg, Germany. Pauli.Tikka@med.uni-heidelberg.de.

Methods in Molecular Biology (Clifton, N.J.)

|February 12, 2019

Summary

This summary is machine-generated.

Mathematical models aid in understanding kidney development, a complex process involving cell migration and differentiation. This review explores various modeling approaches, including computational simulations of early nephron formation.

Keywords:

CompuCell3D Computational modelling Early nephrogenesis Modelling in biology

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Published on: April 7, 2016

Area of Science:

Developmental Biology
Computational Biology
Mathematical Modeling

Background:

Kidney development (nephrogenesis) is a complex process involving intricate cell interactions.
Mathematical modeling offers a powerful framework to understand these biological processes.

Purpose of the Study:

To review methodologies for constructing mathematical models of kidney development.
To illustrate challenges in biological model building using specific examples.

Main Methods:

General description of mathematical modeling in biology and pattern formation.
Assessment of models for kidney branching morphogenesis.
Computational modeling using CompuCell3D and the Cellular Potts Model (CPM).
Modeling of pretubular aggregate (PTA) to renal vesicle (RV) transition.

Main Results:

Exploration of various modeling approaches for nephrogenesis.
Demonstration of computational modeling for early nephron progenitor cell migration.
Illustration of PTA to RV transition modeling based on ureteric bud chemoattractants.

Conclusions:

Mathematical modeling is crucial for dissecting complex developmental processes like kidney formation.
Computational tools like CompuCell3D provide insights into cell behaviors and signaling in nephrogenesis.
Modeling highlights the importance of specific signaling pathways, such as chemoattractants, in kidney development.