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Photocatalytic reductive radical-radical coupling of N,N'-cyclicazomethine imines with difluorobromo derivatives
Peng-Ju Xia1, Zhi-Peng Ye, Dan Song
1College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China. hyangchem@csu.edu.cn xianghaoyue@csu.edu.cn xqchen@csu.edu.cn.
Chemical Communications (Cambridge, England)
|February 14, 2019
Abstract:
A visible-light-induced difluoroalkylation of N,N'-cyclicazomethine imine was successfully realized through a novel photoredox radical-radical cross-coupling reaction. This developed protocol exhibits high functional group tolerance and affords a variety of difluorinated 3-pyrazolidinone scaffolds. Extensive mechanistic investigations have been undertaken, well revealing the involvement of a reductive radical-radical coupling pathway.