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Migraine and increased risk of developing open angle glaucoma: a population-based cohort study
Jehn-Yu Huang1,2, Chien-Chia Su3,4,5, Tsing-Hong Wang1,2
1Department of Ophthalmology, National Taiwan University Hospital College of Medicine, National Taiwan University, No. 7, Chung-Shan S. Rd., Taipei, Taiwan.
BMC Ophthalmology
|February 15, 2019
Summary
Migraine may increase the risk of developing open-angle glaucoma (OAG). This risk is higher in migraineurs without other health conditions, particularly those under 50.
Area of Science:
- Ophthalmology
- Neurology
- Epidemiology
Background:
- Migraine is associated with endothelial dysfunction and systemic vasculopathy.
- Glaucoma patients exhibit systemic vascular diseases, considered vascular risk factors.
- The relationship between migraine and glaucoma risk is not well-established.
Purpose of the Study:
- To investigate the risk of open-angle glaucoma (OAG) in individuals with a history of migraine.
- To determine if migraine is a risk factor for OAG development.
Main Methods:
- A retrospective, population-based cohort study using Taiwan's Longitudinal Health Insurance Database 2000.
- 17,283 migraineurs were compared with 69,132 non-migraineurs over a 10-year follow-up.
- Cox proportional hazards regression analyzed OAG risk, adjusting for age and comorbidities (ACCI score).
Main Results:
- Migraineurs presented with more vascular comorbidities than the comparison group.
- The 10-year incidence of OAG was 1.29 per 1000 person-years for migraineurs vs. 1.02 for controls.
- Migraineurs with no comorbidities (ACCI=0) had a 1.68-fold increased risk of OAG (95% CI, 1.20-2.36).
Conclusions:
- Migraine is linked to an elevated risk of open-angle glaucoma.
- This association is significant in migraineurs under 50 years old with no comorbidities.
- Further research may clarify the underlying pathophysiological mechanisms connecting migraine and OAG.
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