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Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Cancer02:18

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Updated: Jan 29, 2026

A Sensitive Method to Quantify Senescent Cancer Cells
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A Sensitive Method to Quantify Senescent Cancer Cells

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Senescence and Cancer.

Sulin Zeng1,2, Wen H Shen2, Li Liu1

  • 1Department of Microbiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.

Cancer Translational Medicine
|February 16, 2019
PubMed
Summary
This summary is machine-generated.

Cellular senescence can prevent cancer but also promote it via the senescence-associated secretory phenotype (SASP). Understanding senescence regulation is key to overcoming challenges in cancer treatment.

Keywords:
Cancerchemotherapyradiotherapysenescence

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Techniques to Induce and Quantify Cellular Senescence
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Techniques to Induce and Quantify Cellular Senescence

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Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Cellular senescence is a state of irreversible growth arrest.
  • Senescence acts as a tumor suppressor mechanism by preventing proliferation of damaged cells.
  • However, senescence can paradoxically promote cancer progression through the senescence-associated secretory phenotype (SASP).

Purpose of the Study:

  • To review the dual role of senescence in cancer development.
  • To discuss the regulation of senescence by various cellular stresses.
  • To highlight the challenges senescence poses for cancer therapy.

Main Methods:

  • Literature review of senescence and cancer biology.
  • Analysis of oncogene-induced senescence and replicative senescence.
  • Examination of the impact of SASP on the tumor microenvironment.

Main Results:

  • Senescence can be induced by oncogene activation, tumor suppressor loss, and genotoxic stress.
  • Early senescence prevents malignant transformation, while chronic senescence can drive tumorigenesis.
  • SASP contributes to inflammation and promotes tumor growth and metastasis.

Conclusions:

  • Senescence presents a complex, context-dependent role in cancer.
  • Targeting senescence pathways offers potential therapeutic strategies.
  • The dual nature of senescence complicates its clinical application in cancer treatment.