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Updated: Jan 29, 2026
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In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
Published on: July 22, 2014
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Modified MR dispersion imaging in prostate dynamic contrast-enhanced MRI.
1Department of Radiological Sciences, UCLA, Los Angeles, California, USA.
Journal of Magnetic Resonance Imaging : JMRI
|February 19, 2019
Summary
Modified MR dispersion imaging (mMRDI) offers improved prostate cancer detection with minimal error and similar uncertainty. This advanced technique enhances delineation between cancerous and noncancerous tissues in dynamic contrast-enhanced MRI (DCE-MRI).
Area of Science:
- Radiology
- Medical Imaging
- Oncology
Background:
- Previous models for prostate dynamic contrast-enhanced MRI (DCE-MRI) faced computational complexity issues.
- Intravascular dispersion parameter estimation aimed to enhance model accuracy and precision.
Purpose of the Study:
- To compare model fitting uncertainty and error across different DCE-MRI analysis models.
- To evaluate the intravascular dispersion parameter's ability to differentiate prostate tissue types.
Main Methods:
- Retrospective analysis of 53 patients undergoing radical prostatectomy.
- Utilized 3T/3D RF-spoiled gradient echo sequence for DCE-MRI.
- Assessed model fitting uncertainty using coefficient of variation and error with Akaike information criterion.
Main Results:
- Modified MR dispersion imaging (mMRDI) demonstrated minimum model fitting error.
- mMRDI improved delineation of noncancerous from clinically significant prostate cancer in transition (AUC=0.92) and peripheral zones (AUC=0.92).
- MRDI showed lower delineation performance (AUC=0.89 and 0.85).
Conclusions:
- Modified MR dispersion imaging (mMRDI) shows promise for prostate cancer detection.
- mMRDI maintains similar model fitting uncertainty compared to standard models.
- This technique enhances the differentiation of cancerous from noncancerous prostate tissue.
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