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Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
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Controller for microfluidic large-scale integration.

Jonathan A White1, Aaron M Streets1,2

  • 1Department of Bioengineering University of California, Berkeley, CA 94720, United States.

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|February 19, 2019
PubMed
Summary
This summary is machine-generated.

We developed a low-cost, open-source controller called KATARA (Kit for Arduino-based Transistor Array Actuation) to easily manage microfluidic valves. This system simplifies high-throughput assays, making them accessible without specialized engineering skills.

Keywords:
Arduino shieldMicrofluidicsMulti-layer soft lithographyOpen source hardwarePythonSolenoid valve

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Area of Science:

  • Biotechnology
  • Microfluidics
  • Automation

Background:

  • Microfluidic devices enable precise fluid handling for biological and chemical assays.
  • Controlling microfluidic valves often requires specialized engineering knowledge or costly commercial systems.

Purpose of the Study:

  • To present an open-source, low-cost controller for actuating microfluidic valves.
  • To simplify the setup and operation of microfluidic platforms for high-throughput applications.

Main Methods:

  • Development of the Kit for Arduino-based Transistor Array Actuation (KATARA).
  • Utilizing an Arduino microcontroller to drive 70 solenoid valves for pneumatic actuation.
  • Creation of a Python package with a graphical user interface (GUI) for computer control.

Main Results:

  • KATARA provides a cost-effective solution for controlling numerous microfluidic valves.
  • The system enables programmable, pneumatic actuation of integrated microfluidic valves.
  • The accompanying GUI allows operation without requiring programming expertise.

Conclusions:

  • KATARA democratizes the use of advanced microfluidic control systems.
  • This open-source solution reduces barriers to entry for high-throughput microfluidic assays.
  • The system facilitates wider adoption of microfluidics in research and diagnostics.