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Updated: Jan 29, 2026

Determination of the Glycogen Content in Cyanobacteria
Published on: July 17, 2017
Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria
Xiao Liang1, Danmeng Luo1, Jia-Lei Yan2
1Department of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , Gainesville , Florida 32610 , United States.
Abstract:
CXCR7 plays an emerging role in several physiological processes. A linear peptide, amantamide (1), was isolated from marine cyanobacteria, and the structure was determined by NMR and mass spectrometry. The total synthesis was achieved by solid-phase method. After screening two biological target libraries, 1 was identified as a selective CXCR7 agonist. The selective activation of CXCR7 by 1 could provide the basis for developing CXCR7-targeted therapeutics and deciphering the role of CXCR7 in different diseases.
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