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Multimodal gradients across mouse cortex.

Ben D Fulcher1, John D Murray2, Valerio Zerbi3

  • 1School of Physics, Sydney University, Sydney, NSW 2006, Australia; ben.fulcher@sydney.edu.au xjwang@nyu.edu.

Proceedings of the National Academy of Sciences of the United States of America
|February 21, 2019
PubMed
Summary
This summary is machine-generated.

Mammalian brain organization shows conserved hierarchical gradients across species. This study reveals similar spatial patterns in mouse and human cortex, suggesting a fundamental principle of brain structure.

Keywords:
cortical gradientscortical hierarchygene expressioninterspecies comparison

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Area of Science:

  • Neuroscience
  • Comparative Anatomy
  • Genomics

Background:

  • Primate cerebral cortex exhibits hierarchical organization from sensorimotor to association areas.
  • Understanding if these hierarchical gradients are unique to primates or conserved in mammals is crucial.

Purpose of the Study:

  • To investigate the topographic similarity of large-scale gradients in mouse and primate cortex.
  • To determine if conserved mammalian principles underlie cortical organization.

Main Methods:

  • Analysis of cytoarchitecture, gene expression, interneuron densities, and axonal connectivity in mouse cortex.
  • Utilizing T1-weighted:T2-weighted (T1w:T2w) magnetic resonance imaging for cross-species spatial reference.
  • Comparison of gene transcriptional maps between mouse and human cortex.

Main Results:

  • Identified large-scale gradients in mouse cortex varying from sensory to prefrontal areas.
  • Reported topographic similarity and interspecies agreement in cortical gradients between mouse and human.
  • Found significant correspondence between mouse and human gene expression maps.

Conclusions:

  • Cortical organization exhibits systematic structural variation across areas, a core principle in mammalian brains.
  • Hierarchical specialization in mammalian brains may be underpinned by these conserved structural gradients.
  • Highlights an underappreciated spatial dimension of mouse cortical specialization.