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Biological consequences of drug sulphoxidation
1Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Paddington, London, U.K.
Drug Metabolism and Drug Interactions
|January 1, 1988
Abstract:
The addition of an oxygen atom to the sulphur centre of a compound, with the formation of a polarized S-O moiety, alters the physical and chemical properties of the molecule and can profoundly influence its biological activity, its disposition within the body and its potential fate. Examples are given to illustrate these points.