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Updated: Jan 28, 2026
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The Use of Thermal Infra-Red Imaging to Detect Delayed Onset Muscle Soreness
Published on: January 22, 2012
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Delayed-Onset Nodules to Differentially Crosslinked Hyaluronic Acids: Comparative Incidence and Risk Assessment
Mona Sadeghpour1,2, Nicola A Quatrano1, Lauren Meshkov Bonati1
1SkinCare Physicians, Chestnut Hill, Massachusetts.
Summary
Delayed nodules from hyaluronic acid (HA) fillers, specifically Vycross (VYC) types, occurred in 1.0% of patients. This suggests VYC HA fillers may have a higher incidence of delayed nodules than other fillers.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Biomaterials Science
Background:
- Limited data exists on the true incidence of delayed-onset nodules and immune tolerance associated with hyaluronic acid (HA) fillers.
- Understanding these factors is crucial for patient safety and effective aesthetic treatments.
Purpose of the Study:
- To determine the incidence of delayed nodules in Vycross (VYC) HA fillers.
- To compare this incidence with previously reported data for all HA fillers, including those approved by the FDA.
Main Methods:
- A retrospective chart review was conducted for patients receiving VYC fillers over 12 months.
- Nodule incidence for nonanimal-stabilized hyaluronic acid (NASHA) fillers was analyzed using FDA Safety and Effectiveness Data.
Main Results:
- Out of 1,029 patients and 1,250 VYC treatments, five patients (1.0% per patient, 0.8% per syringe) developed delayed nodules with VOB.
- No nodules were observed with VLR or VOL fillers.
- All nodules were successfully treated with intralesional triamcinolone and hyaluronidase.
Conclusions:
- Vycross (VYC) HA fillers, particularly VOB, may be associated with a higher incidence of delayed nodules compared to other NASHA fillers.
- The VYC HA formulation might alter immune tolerance, leading to increased delayed nodule formation.
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