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Numerical evaluation and experimental validation of cross-flow microfiltration device design.

Marisel De Jesús Vega1, Joseph Wakim1, Nese Orbey2

  • 1Department of Chemical Engineering, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA, 01854, USA.

Biomedical Microdevices
|February 22, 2019
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Summary

This study optimized a cross-flow microfiltration device for microsphere separation. Smaller pillars and specific layouts improved efficiency, with silicon devices showing higher retention of larger microspheres.

Keywords:
COMSOL simulationsCross-flow microfiltrationMicrofluidic deviceOptimizationTesting with microspheres

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Separation Science

Background:

  • Microfluidic devices are crucial for cell separation.
  • Optimizing flow patterns and device geometry is key for efficient separation.

Purpose of the Study:

  • To design and validate a cross-flow microfiltration device for size-based microsphere separation.
  • To investigate the impact of pillar size, shape, and layout on fluid dynamics and filtration performance.

Main Methods:

  • Computational fluid dynamics (CFD) simulations were used to analyze flow patterns.
  • Microfluidic devices were fabricated using polydimethylsiloxane (PDMS) and silicon.
  • Experimental validation involved separating microspheres of varying sizes.

Main Results:

  • Pillar size significantly impacts filtration capacity; 10 μm pillars were more effective than 20 μm.
  • Pillar shape influenced side-channel velocities, with triangular and square pillars reducing flow.
  • Silicon devices achieved 95-100% retention of large microspheres, while PDMS devices showed lower efficiency and increased sphere agglomeration.

Conclusions:

  • Device design parameters, including pillar geometry and layout, critically affect microfiltration performance.
  • Silicon microfluidic devices offer superior performance for large microsphere retention compared to PDMS.
  • PDMS devices present a cost-effective alternative for applications where high retention efficiency is not paramount.