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Evolution of brain network dynamics in neurodevelopment.

Lucy R Chai¹, Ankit N Khambhati¹, Rastko Ciric²

¹Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 USA.

Network Neuroscience (Cambridge, Mass.)

|February 23, 2019

Summary

This summary is machine-generated.

Brain network interactions become more flexible during development. This study tracked brain graph dynamics in youth, revealing increased executive system network expression and switching from childhood to young adulthood.

Keywords:

Energy Entropy Executive function Flexibility Matrix factorization Neurodevelopment Subgraph

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Modeling the Functional Network for Spatial Navigation in the Human Brain

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Published on: October 13, 2023

Area of Science:

Neuroscience
Developmental Psychology
Network Science

Background:

Cognitive functions develop significantly throughout childhood and adolescence.
Understanding the brain's network structure and its dynamic changes during development is crucial for explaining behavioral flexibility.
Current knowledge on how brain network graphs evolve from childhood to adulthood remains limited.

Purpose of the Study:

To investigate the structural and dynamic changes in brain networks during development.
To identify specific brain subgraphs that characterize cognitive development.
To explore the relationship between network dynamics and executive functions.

Main Methods:

Applied a novel machine-learning approach to analyze resting-state brain activity.
Tracked time-varying and overlapping subgraphs within a cohort of 200 healthy youth (ages 8-22).
Utilized data from the Philadelphia Neurodevelopmental Cohort.

Main Results:

Identified a set of brain subgraphs exhibiting integrated and dynamic interactions.
Observed that highly expressed subgraphs were transient, with flexible switching over time.
Found a significant increase in the expression and flexibility of a frontoparietal executive system subgraph from childhood to young adulthood.

Conclusions:

Healthy neurodevelopment is associated with the increasing prominence of executive networks.
Brain development involves enhanced dynamic switching within and between brain regions supporting cognitive functions.
The findings provide insights into the neural basis of cognitive flexibility across development.