Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nursing Clinical Information System01:27

Nursing Clinical Information System

1.3K
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
1.3K
Clinical Trials01:16

Clinical Trials

10.4K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.4K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.9K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.5K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.5K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

715
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
715

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human Development Index and outcomes in older critically ill patients: A European multicentre study.

Annals of intensive care·2026
Same author

The Use of Body Mass Index Polygenic Risk Score (BMI-PRS) in a Paediatric Population With Obesity.

Pediatric obesity·2026
Same author

Uric acid and subclinical atherosclerosis: distinct associations across coronary and carotid arteries.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

Poor self-rated health is twice as common in rheumatoid arthritis: population-based evidence from the Paracelsus 10,000 study.

Clinical and experimental medicine·2026
Same author

Alcohol intake reprograms hepatic immune-metabolic circuits to exacerbate murine atherosclerosis and human cardiovascular risk.

JHEP reports : innovation in hepatology·2026
Same author

Sex and 30-day mortality in elderly critically Ill adults: A frailty-adjusted multinational analysis with frequentist and bayesian estimates.

European journal of internal medicine·2026

Related Experiment Video

Updated: Jan 28, 2026

Determining the Phagocytic Activity of Clinical Antibody Samples
09:05

Determining the Phagocytic Activity of Clinical Antibody Samples

Published on: November 30, 2011

24.1K

Clinical implications of fetuin-A.

Peter Jirak1, Lars Stechemesser2, Elena Moré2

  • 1Department of Internal Medicine II, Division of Cardiology, Paracelsus Medical University, Salzburg, Austria.

Advances in Clinical Chemistry
|February 25, 2019
PubMed
Summary
This summary is machine-generated.

Fetuin-A, a hepatokine, is a protein derived from hepatocytes with diverse biological roles. This glycoprotein is crucial in various physiological processes.

Keywords:
AtherosclerosisCalcificationCardiovascular diseaseChronic kidney diseaseFetuin-A

More Related Videos

Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.9K
Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
07:49

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Published on: September 17, 2014

11.9K

Related Experiment Videos

Last Updated: Jan 28, 2026

Determining the Phagocytic Activity of Clinical Antibody Samples
09:05

Determining the Phagocytic Activity of Clinical Antibody Samples

Published on: November 30, 2011

24.1K
Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.9K
Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
07:49

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Published on: September 17, 2014

11.9K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Fetuin-A, also known as alpha2-Heremans-Schmid glycoprotein, is a 46kDa protein produced by the liver.
  • As a hepatokine, Fetuin-A circulates in the bloodstream and influences various extrahepatic tissues.
  • Its multifaceted functions are increasingly recognized in metabolic and inflammatory pathways.

Purpose of the Study:

  • To elucidate the diverse functional roles of Fetuin-A.
  • To investigate the molecular mechanisms underlying Fetuin-A's physiological impact.
  • To explore Fetuin-A's involvement in disease pathogenesis.

Main Methods:

  • Protein analysis and characterization of Fetuin-A.
  • In vitro cell culture studies to assess cellular responses.
  • In vivo animal models to study systemic effects.
  • Biochemical assays to determine molecular interactions.

Main Results:

  • Fetuin-A exhibits significant roles in glucose metabolism and insulin sensitivity.
  • The protein is implicated in modulating inflammatory responses.
  • Fetuin-A has been identified as a key player in cardiovascular health and calcification processes.
  • Its involvement in bone metabolism and development is also noted.

Conclusions:

  • Fetuin-A is a critical hepatokine with diverse physiological functions.
  • Understanding Fetuin-A's roles is essential for developing therapeutic strategies for metabolic and inflammatory diseases.
  • Further research into Fetuin-A's mechanisms will provide deeper insights into its clinical relevance.