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Updated: Jan 28, 2026
06:39
Live Cell Imaging of Chromosome Segregation During Mitosis
Published on: March 14, 2018
9.9K
Poring over chromosomes: mitotic nuclear pore complex segregation.
Subbulakshmi Suresh1, Stephen A Osmani1
1Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA.
Current Opinion in Cell Biology
|February 25, 2019
Summary
Understanding how nuclear pore complexes (NPCs) are inherited during cell division is crucial. This review explores mitotic NPC segregation and assembly, suggesting chromatin-based mechanisms may apply to vertebrate cells.
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- Eukaryotic cells require nucleocytoplasmic transport via Nuclear Pore Complexes (NPCs) for survival.
- NPCs are vital for cellular functions beyond transport, including mitosis, DNA repair, and gene regulation.
- Dysregulation of NPCs is linked to various diseases, yet their inheritance during mitosis remains unclear.
Purpose of the Study:
- To review recent findings on the mechanisms of mitotic NPC segregation and assembly in mammals.
- To discuss the role of the chromatin-associated protein Nup2 in NPC inheritance in Aspergillus nidulans.
- To propose potential chromatin-based mechanisms for NPC inheritance in vertebrate cells.
Main Methods:
- Literature review of recent research on NPC function and inheritance during mitosis.
- Comparative analysis of NPC segregation and assembly mechanisms across different organisms.
- Exploration of chromatin-based regulation of NPC proteins.
Main Results:
- Recent insights into mammalian mitotic NPC segregation and assembly processes have emerged.
- The fungal protein Nup2, localized to mitotic chromatin, plays a role in NPC inheritance.
- Chromatin-based mechanisms governing NPC inheritance are proposed.
Conclusions:
- Faithful inheritance of NPCs during mitosis is essential for cellular function and disease prevention.
- Mechanisms involving mitotic chromatin, such as those seen with Nup2, may be conserved in vertebrate cells.
- Further research is needed to elucidate the precise mechanisms of NPC inheritance in mammals.
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