Related Experiment Video

Updated: Jan 28, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.5K

Predictors of malignant brain edema after mechanical thrombectomy for acute ischemic stroke

Xianjun Huang1, Qian Yang1, Xiaolei Shi1

  • 1Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.

Journal of Neurointerventional Surgery
|February 25, 2019
PubMed
Abstract

Insights

Malignant brain edema (MBE) occurred in 26.9% of patients after mechanical thrombectomy (MT), leading to worse functional outcomes and higher mortality. Internal carotid artery occlusion and poor collateral status predict MBE development.

Area of Science:

  • Neurology
  • Stroke Medicine
  • Interventional Neuroradiology

Background:

  • Malignant brain edema (MBE) is a severe complication following ischemic stroke.
  • Data regarding MBE incidence and outcomes after mechanical thrombectomy (MT) are limited.

Purpose of the Study:

  • To determine the incidence, predictors, and clinical outcomes of MBE in patients undergoing MT.
  • To identify factors associated with MBE development even after successful recanalization.

Main Methods:

  • A cohort of 130 patients with anterior circulation large vessel occlusion stroke treated with MT was analyzed.
  • MBE was defined as a midline shift of ≥5 mm on follow-up imaging within 72 hours.
  • Functional outcomes were assessed using the 90-day modified Rankin Scale score.

Main Results:

  • MBE developed in 26.9% of patients, associated with significantly worse functional independence and higher 90-day mortality.
  • In patients with successful recanalization, MBE occurred in 23.1%.
  • Internal carotid artery occlusion and poorer collateral status were independently associated with MBE development.

Conclusions:

  • MBE is a significant complication after MT, impacting functional outcomes and survival.
  • Vessel occlusion location and collateral circulation are crucial factors in MBE pathogenesis post-MT.
Keywords:
complicationstrokethrombectomy

More Related Videos

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples04:32

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Published on: October 23, 2020

8.7K
Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema08:44

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Published on: September 1, 2016

9.3K

Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.1K
Reaction Mechanisms03:06

Reaction Mechanisms

Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
30.7K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.4K
Mechanical Protein Functions01:58

Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
5.6K
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
4.1K
Cardiac Output and Stroke Volume01:11

Cardiac Output and Stroke Volume

Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac...
4.8K