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Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion
Published on: March 1, 2019
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Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral
Min Cheol Chang1, Chae Ri Park2, Seung Hwa Rhie3
1Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea.
Neural Regeneration Research
|February 27, 2019
Summary
Early treadmill exercise improved motor and neuronal recovery after ischemic stroke in rats. This recovery was linked to increased levels of macrophage migration inhibitory factor (MIF) and brain-derived neurotrophic factor (BDNF) in the brain.
Area of Science:
- Neuroscience
- Exercise Physiology
- Stroke Research
Background:
- Macrophage migration inhibitory factor (MIF) neuroprotective function in ischemic stroke is under-investigated.
- Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal survival and plasticity.
Purpose of the Study:
- To investigate the effects of early treadmill exercise on recovery from ischemic stroke.
- To determine if exercise-induced recovery is associated with MIF and BDNF expression in the ischemic area.
Main Methods:
- Middle cerebral artery occlusion (MCAO) model in Sprague-Dawley rats.
- Groups included MCAO with exercise (MCAO-Ex), MCAO sedentary (MCAO-St), sham with exercise (Sham-Ex), and sham sedentary (Sham-St).
- Exercise involved 30 minutes daily treadmill running for 5 days, starting 48 hours post-MCAO.
Main Results:
- The MCAO-Ex group showed improved motor function (longer wire hang time) and higher white matter integrity (relative fractional anisotropy) in the peri-infarct region compared to MCAO-St.
- Expression levels of MIF and BDNF were upregulated in the peri-infarct region of MCAO-Ex rats.
- Increased MIF and BDNF levels positively correlated with improved white matter integrity.
Conclusions:
- Early treadmill exercise initiated 48 hours after MCAO enhances motor and neuronal recovery after ischemic stroke.
- Upregulation of MIF and BDNF in the peri-infarct region is a potential mechanism underlying exercise-induced neurological recovery.
- Exercise did not affect MIF or BDNF levels in sham-operated rats, indicating a stroke-specific effect.
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