Related Experiment Video
Updated: Jan 28, 2026

Evaluation of the Storage Stability of Extracellular Vesicles
Published on: May 22, 2019
Separating extracellular vesicles and lipoproteins via acoustofluidics
Mengxi Wu1, Chuyi Chen, Zeyu Wang
1Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27707, USA. tony.huang@duke.edu.
Abstract:
Extracellular vesicles (EVs) and lipoproteins are abundant and co-exist in blood. Both have been proven to be valuable as diagnostic biomarkers and for therapeutics. However, EVs and lipoproteins are both on the submicron scale and overlap in size distributions. Conventional methods to separate EVs and lipoproteins are inefficient and time-consuming. Here we present an acoustofluidic-based separation technique that is based on the acoustic property differences of EVs and lipoproteins. By using the acoustofluidic technology, EVs and subgroups of lipoproteins are separated in a label-free, contact-free, and continuous manner. With its ability for simple, rapid, efficient, continuous-flow isolation, our acoustofluidic technology could be a valuable tool for health monitoring, disease diagnosis, and personalized medicine.
More Related Videos
Related Concept Videos
The Extracellular Matrix
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Separation of Sister Chromatids
At the onset of anaphase, separase, a proteolytic enzyme, is...
Optimizing Chromatographic Separations
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...
Separable Differential Equations
Overview Of Cell Separation And Isolation

