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Parameters for Validating a Hospital Pneumatic Tube System.

Christopher W Farnsworth1, Daniel M Webber1, James A Krekeler1

  • 1Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University, St. Louis, MO.

Clinical Chemistry
|February 28, 2019
PubMed
Summary
This summary is machine-generated.

Hospital pneumatic tube systems (PTSs) can be validated by measuring accelerations and their effect on blood analytes like lactate dehydrogenase (LD). This method helps predict and prevent inaccurate lab results from sample transport stress.

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Biomedical Engineering

Background:

  • Pneumatic tube systems (PTSs) rapidly transport patient blood samples.
  • PTS transport can cause physical stress, leading to blood cell damage and altered test results.
  • Validation methods for hospital PTS are not well-established.

Purpose of the Study:

  • To compare accelerometers for evaluating PTS routes.
  • To assess variability in PTS forces and their impact on blood analytes.
  • To develop a method for validating hospital PTS to ensure accurate laboratory results.

Main Methods:

  • Two accelerometers were compared across multiple PTS routes.
  • Variability in PTS forces was assessed over time for specific routes.
  • Response curves were generated linking acceleration to lactate dehydrogenase (LD), hemolysis, and potassium levels.

Main Results:

  • Maximum recorded g-forces reached 22g.
  • Significant day-to-day variation in acceleration (CV 4%-39%) was observed within routes.
  • Two PTS routes were predicted to increase LD by ≥20%, consistent with patient data.

Conclusions:

  • Hospital PTS can be validated by correlating plasma analyte concentrations (e.g., LD) with accelerometer-recorded forces.
  • This validation method is inexpensive, simple, and robust.
  • Documenting the relationship between PTS forces and analyte changes ensures reliable sample transport.