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Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study
Hongli Yang1, Haomin Luo1,2, Stuart K Gardiner3
1Devers Eye Institute, Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, United States.
Investigative Ophthalmology & Visual Science
|February 28, 2019
Summary
Peripapillary choroidal thickness (PCT) is thinner in older individuals and those with longer axial length. This finding is most pronounced in the inferior temporal regions of the eye.
Area of Science:
- Ophthalmology
- Optometry
- Medical Imaging
Background:
- Peripapillary choroidal thickness (PCT) is a key indicator of ocular health.
- Understanding factors influencing PCT is crucial for diagnosing and managing various eye conditions.
Purpose of the Study:
- To quantify peripapillary choroidal thickness (PCT) in a diverse healthy population.
- To identify demographic and ocular factors influencing PCT.
Main Methods:
- 362 healthy participants underwent enhanced depth imaging optical coherence tomography (OCT).
- PCT was measured at multiple distances from the anterior scleral canal opening (ASCO).
- Statistical analyses (ANOVA, regression) assessed the impact of age, axial length, IOP, ethnicity, sex, sector, and ASCO area.
Main Results:
- PCT decreased with older age, longer axial length, larger ASCO area, European descent, and female sex.
- Age and axial length were the most significant factors influencing PCT.
- Inferior-temporal sectors showed the thinnest PCT and the fastest age-related decline.
Conclusions:
- Healthy eyes exhibit thinner PCT in inferior-temporal sectors.
- Older age, longer axial length, larger ASCO area, European ethnicity, and female sex are associated with thinner PCT.
- Age has the most substantial impact on PCT, particularly in the inferior-temporal regions.
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