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Updated: Jan 28, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
Published on: October 16, 2016
[Regulation of osteoblasts and chondrocytes by Wnt signaling.]
Riko Nishimura1, Kenji Hata1, Jumpei Kida1
1Department of Molecular & Cellular Biochemistry,Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Abstract:
Wnt plays important roles in regulation of differentiation of osteoblast and chondrocyte and their function. Wnt family members ingeniously utilize canonical Wnt signaling pathway through β-catenin and non-canonical Wnt signaling pathway independent of β-catenin, consequently regulating development, formation and homeostasis of bone and cartilage. Recent studies revealed that canonical Wnt signal activates transcriptional regulator, TAZ, in addition to transcription factors, LEF and TCF. Canonical Wnt signal crosstalks with BMP signal by stimulating complex formation of LEF1, TAZ and Runx2. Although molecular mechanism of non-canonical Wnt signal is getting clearer, the precise role of non-canonical Wnt signal in bone and cartilage seems still elusive.
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