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Post Traumatic Stress Disorder and Substance Use Disorder as Two Pathologies Affecting Memory Reactivation:
Pascale Gisquet-Verrier1, Claire Le Dorze1
1Institut des Neurosciences Paris-Saclay (Neuro-PSI), Université Paris-Sud, CNRS UMR 9197, Université Paris-Saclay, Orsay, France.
Frontiers in Behavioral Neuroscience
|March 1, 2019
Summary
Post-traumatic stress disorder (PTSD) and substance use disorder (SUD) share memory-related dysfunctions. Treating them as memory disorders using novel memory reprocessing techniques shows promise for effective treatment.
Area of Science:
- Neuroscience
- Psychiatry
- Memory Research
Background:
- Post-traumatic stress disorder (PTSD) and substance use disorder (SUD) are distinct conditions with high comorbidity.
- Both disorders may stem from shared physiological dysfunctions and exhibit similar characteristics.
Purpose of the Study:
- To review evidence suggesting PTSD and SUD are disorders of memory.
- To explore novel therapeutic strategies targeting pathological memory reprocessing.
Main Methods:
- Review of existing literature on PTSD, SUD, and memory consolidation/reconsolidation.
- Examination of therapeutic interventions like extinction therapy, reconsolidation blockade, state dependency, and emotional remodeling.
Main Results:
- PTSD and SUD share characteristics and may arise from common memory-related physiological dysfunctions.
- Reactivation-dependent memory malleability offers new therapeutic avenues.
- Innovative treatments like state dependency and emotional remodeling show encouraging results.
Conclusions:
- Viewing PTSD and SUD as memory disorders, specifically related to hyperreactivity to reminders, provides a unified therapeutic perspective.
- Targeting pathological memory reprocessing through novel techniques offers promising treatment strategies for both PTSD and SUD.
Keywords:
memory integrationmemory reactivationpost-traumatic stress disorder (PTSD)reconsolidation blockadestate dependencyMore Related Videos
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