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In vivo 19F MRI for Cell Tracking
Published on: November 25, 2013
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Markerless high-frequency prospective motion correction for neuroanatomical MRI
Robert Frost1,2, Paul Wighton1, F Işık Karahanoğlu1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts.
Magnetic Resonance in Medicine
|March 2, 2019
Summary
Markerless head tracking enables prospective motion correction (PMC) during MRI. High-frequency, within-echo-train PMC significantly reduces motion artifacts in neuroimaging, improving accuracy.
Area of Science:
- Medical Imaging
- Neuroimaging
- Biomedical Engineering
Background:
- Head motion is a significant source of artifacts in neuroanatomical MRI.
- Prospective motion correction (PMC) aims to minimize these artifacts by adjusting imaging parameters in real-time.
- High-frequency motion correction during echo trains is crucial for sequences with long acquisition times.
Purpose of the Study:
- To integrate markerless head motion tracking with prospectively corrected neuroanatomical MRI sequences.
- To investigate the efficacy of high-frequency motion correction within imaging echo trains.
Main Methods:
- A commercial 3D surface tracking system was used for markerless head motion estimation.
- Imaging field of view (FOV) was adapted during MPRAGE and T2 SPACE sequences based on real-time motion tracking.
- Within-echo-train PMC (updating FOV every <50 ms) was compared to before-echo-train PMC (updating once per TR).
- Continuous-motion experiments with phantoms and in vivo were conducted.
Main Results:
- Markerless tracking demonstrated high accuracy in estimating head pose compared to MR image registration.
- Within-echo-train PMC significantly reduced motion artifacts compared to before-echo-train PMC.
- T2 SPACE sequences were more sensitive to motion during echo trains than MPRAGE.
- Morphometry estimates using FreeSurfer on within-echo-train PMC MPRAGE images were the most accurate.
Conclusions:
- Markerless head tracking is a viable method for implementing PMC in neuroimaging.
- High-frequency, within-echo-train PMC effectively reduces motion sensitivity in long echo train sequences.
- This technique enhances the accuracy of neuroanatomical MRI and subsequent morphometric analysis.
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