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Seizures associated with oxamniquine therapy.

H Stokvis, A G Bauer, P C Stuiver

    The American Journal of Tropical Medicine and Hygiene
    |March 1, 1986
    PubMed
    Summary

    Oxamniquine, used to treat schistosomiasis mansoni, may cause generalized seizures. This potential side effect might be more frequent than previously recognized, with certain ethnic groups potentially at higher risk.

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    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Neurology

    Background:

    • Schistosomiasis mansoni is a parasitic disease prevalent in tropical and subtropical regions.
    • Oxamniquine is a key therapeutic agent for treating schistosomiasis mansoni infections.

    Observation:

    • Generalized seizures were observed in three patients undergoing oxamniquine treatment.
    • This adverse event occurred despite standard therapeutic protocols.

    Findings:

    • Oxamniquine treatment for schistosomiasis mansoni is associated with a risk of generalized seizures.
    • The incidence of this adverse effect may be underestimated in current literature.

    Implications:

    • Clinicians should be vigilant for seizure activity in patients treated with oxamniquine.
    • Further research is warranted to identify specific ethnic predispositions to this oxamniquine-induced adverse event.

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