Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coagulation and immunology.

S R Saba, R E Domen

    Clinics in Laboratory Medicine
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Vertebrate hemostasis relies on blood components and vascular interactions. Immune responses involving antibodies can disrupt coagulation, potentially causing bleeding disorders and hemorrhagic diathesis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cardiac natriuretic peptides: hormones with anticancer effects that localize to nucleus, cytoplasm, endothelium, and fibroblasts of human cancers.

    Histology and histopathology·2006
    Same author

    Acute autoimmune hemolytic anemia following DTP vaccination: report of a fatal case and review of the literature.

    Clinical pediatrics·2002
    Same author

    IL-1 and TNF independent pathways mediate ICAM-1/VCAM-1 up-regulation in ischemia reperfusion injury.

    Journal of leukocyte biology·2001
    Same author

    Promotion and tenure policies.

    American journal of clinical pathology·2001
    Same author

    Transfusion-related acute lung injury secondary to biologically active mediators.

    Archives of pathology & laboratory medicine·2001
    Same author

    Nonaccredited medical education in the United States.

    The New England journal of medicine·2000
    Same journal

    Advances in Hemostasis Laboratory Testing.

    Clinics in laboratory medicine·2026
    Same journal

    Extracellular Vesicles in Hemostasis.

    Clinics in laboratory medicine·2026
    Same journal

    Thrombin Generation Assay: Ready for Prime Time.

    Clinics in laboratory medicine·2026
    Same journal

    Viscoelastic Testing for the Laboratorian: Recent Advances and Practical Advice.

    Clinics in laboratory medicine·2026
    Same journal

    Practical Recommendations for Harmonization of Hemostasis Testing Across Hospital Sites.

    Clinics in laboratory medicine·2026
    Same journal

    The Role of Hypoxia in Vascular Endothelial Dysfunction and Venous Thromboembolism.

    Clinics in laboratory medicine·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Immunology
    • Hematology

    Background:

    • Hemostasis, crucial for vertebrates, involves complex interactions between vascular walls and blood components like coagulation factors, immunoglobulins, and complement.
    • Deficiencies in coagulation factors are a primary cause of bleeding disorders.
    • The immune system's response to foreign or altered self-proteins can lead to antibody production.

    Purpose of the Study:

    • To elucidate the intricate relationship between immune system activation and hemostasis.
    • To understand how antibody-antigen interactions influence coagulation processes.
    • To explore the mechanisms leading to abnormal coagulation and hemorrhagic diathesis.

    Main Methods:

    • Review of existing literature on coagulation, fibrinolysis, and immunology.

    Related Experiment Videos

  • Analysis of molecular interactions between antibodies and coagulation factors.
  • Case study analysis of patients with immune-mediated bleeding disorders.

    • Main Results:

    • Antibody-antigen interactions can directly interfere with coagulation factor function.
    • Immune responses can trigger pro-coagulant or anti-coagulant effects, depending on the specific antibodies involved.
    • Abnormal coagulation cascades resulting from immune dysregulation are linked to hemorrhagic diathesis.

    Conclusions:

    • The immune system plays a significant role in regulating hemostasis.
    • Immune-mediated disruption of coagulation is a critical factor in the development of bleeding disorders.
    • Targeting immune responses may offer novel therapeutic strategies for hemorrhagic conditions.