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The Application of Microfluidic Techniques on Tissue Engineering in Orthopaedics
Lingtian Wang1, Dajun Jiang1, Qiyang Wang1
1Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
Current Pharmaceutical Design
|March 5, 2019
Summary
Microfluidic techniques enhance tissue engineering (TE) for orthopaedics by improving cell culture and creating organized scaffolds. This fusion offers a promising future for treating bone and cartilage defects and metastasis.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Microfluidics
Background:
- Tissue engineering (TE) addresses orthopaedic issues like bone defects and metastasis.
- Traditional TE methods face limitations in cell culture microenvironments and scaffold organization.
- Microfluidics offers solutions to overcome these TE limitations.
Purpose of the Study:
- To review recent advances in microfluidic techniques for tissue engineering in orthopaedics.
- To highlight the benefits of microfluidics in cell cultivation and scaffold fabrication.
- To discuss the potential of microfluidics in studying bone metastasis models.
Main Methods:
- Literature review using PubMed.
- Analysis of microfluidic applications in osteocytic and chondrocytic cell culture.
- Examination of microfluidic-based scaffold fabrication and biomaterial production.
- Review of microfluidic platforms for bone metastasis modeling.
Main Results:
- Microfluidics provides 3-D networks and fluid flows, maintaining osteocytic and chondrocytic cell phenotype and viability.
- Precise control of flows in microfluidic devices enables highly organized scaffold construction.
- Microfluidic platforms facilitate advanced cell culture and biomaterial development for orthopaedic TE.
Conclusions:
- The integration of microfluidics and TE shows significant potential for osteocytic cell culture and scaffold fabrication.
- Microfluidics offers a promising future for advancing tissue engineering applications in orthopaedics.
- Further research is needed to address existing challenges and fully exploit microfluidic capabilities in TE.
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