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[MODIFICATION OF CARDIOVASCULAR RISK WITH A COMBINATION OF METABOLIC SYNDROME AND VEGETATIVE NERVOUS DYSFUNCTION].

A Tursynbekova¹, K Karibaev¹, G Tokmurziyeva¹

¹JSC "Central Clinical Hospital," Almaty; Kazakhstan Medical University "HSPHC" Almaty, Kazakhstan; Research, Cardiac Rehabilitation Institute, Sheba Medical Center, Tel-Aviv University, Israel; City Clinical Hospital №5 Almaty, Kazakhstan.

Georgian Medical News

|March 5, 2019

Summary

This summary is machine-generated.

Autonomic dysfunction, a condition affecting the vegetative nervous system, significantly increases cardiovascular risk in individuals with metabolic syndrome. This highlights the importance of monitoring both conditions together for better patient outcomes.

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Area of Science:

Cardiology
Endocrinology
Neurology

Background:

Metabolic syndrome (MS) is a cluster of conditions increasing cardiovascular disease (CVD) risk.
Vegetative nervous dysfunction (VND) impacts the autonomic nervous system's regulation of bodily functions.
The interplay between MS and VND in CVD risk stratification requires further investigation.

Purpose of the Study:

To determine the effect of vegetative nervous dysfunction (VND) on cardiovascular risk in patients with metabolic syndrome (MS).
To assess the combined prevalence and impact of MS and VND on acute cardiovascular and cerebrovascular events.

Main Methods:

A cohort of 750 civil servants (35-70 years) was monitored.
Metabolic syndrome diagnosed using IDF and AHA/NHLBI criteria.
Variational intervalometry assessed vegetative nervous regulation of hemodynamics.
Acute coronary syndrome, stroke, and peripheral arterial events served as study endpoints.

Main Results:

Metabolic syndrome prevalence was 40.3%; VND was present in 45.6%.
The combined occurrence of MS and VND (21.7%) was significantly higher than expected for independent conditions.
Patients with both MS and VND exhibited a significantly higher incidence of acute regional circulation disturbances compared to those without both conditions.

Conclusions:

Autonomic dysfunction is associated with metabolic syndrome.
VND acts as a modifying factor, increasing cardiovascular complication risk in individuals with MS.
Integrated monitoring of MS and VND is crucial for comprehensive cardiovascular risk management.