[PECULIARITIES OF STRUCTURAL CHANGES IN RAT LUNGS IN APPLICATION OF DIFFERENT METHODS OF REHYDRATION AFTER GENERAL...

Dehydration of the organism leads to the disturbances in homeostasis and structural changes in the lungs. Inadequate rehydration can also lead to the undesirable consequences. Experiments were carried out on rats, which modeled general dehydration and its correction: with metered potable water consumption, with water consumption without restrictions and correction by using a physiological solution. It was established that total dehydration leads to a decrease in the mass of the organ, the thinning of the interalveolar partitions with simultaneous decrease in the diameter and area of the alveolar section, as well as a decrease in the thickness of the multi-row blinking epithelium of the bronchi. Such changes occur on the background of ascending vasoconstriction of the small and middle branches of the pulmonary arteries with simultaneous expansion and increase in the capacity of the large diameter branches. Rehydration without water restriction enhances circulatory disorders with the development of edema in the parenchyma and peribronhial and paravazal spaces, with the formation of perdiopedic hemorrhages. When applying a physiological solution without restrictions, the nature of structural changes in the lungs was similar, albeit less pronounced. The most effective was the dosed correction of potable water.