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Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
Published on: September 14, 2018
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Dupilumab for Systemic Allergy Syndrome With Dermatitis
Sharon E Jacob, Calvin T Sung1, Brian C Machler2
1School of Medicine, University of California, Riverside.
Dermatitis : Contact, Atopic, Occupational, Drug
|March 5, 2019
Summary
Dupilumab shows promise for treating severe allergic contact dermatitis (ACD) in patients unresponsive to standard therapies. This systemic allergy treatment may improve quality of life for those with recalcitrant ACD.
Area of Science:
- Immunology
- Dermatology
Background:
- Allergic contact dermatitis (ACD) is traditionally viewed as a TH1-mediated reaction.
- No FDA-approved systemic therapies currently exist for ACD.
- Some ACD patients have concomitant atopic dermatitis and systemic allergic dermatitis from dietary allergens.
Observation:
- ACD involves complex interactions between TH1 and TH2 immune responses.
- A subgroup of patients with systemic allergy to Balsam of Peru or nickel were studied.
- These patients experienced significant improvement with dupilumab treatment.
Findings:
- Dupilumab treatment led to remarkable improvement in patients with recalcitrant ACD.
- Patients regained quality of life without strict dietary adherence.
- The study suggests dupilumab's efficacy in a specific ACD subgroup.
Implications:
- Dupilumab may offer a new systemic treatment option for refractory ACD.
- This finding could benefit patients with severe, diet-unresponsive ACD.
- Further research into dupilumab's role in ACD is warranted.
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