Related Experiment Video
Updated: Jan 28, 2026
04:37
Finger-stick Blood Sampling Methodology for the Determination of Exercise-induced Lymphocyte Apoptosis
Published on: February 24, 2011
12.5K
Analytical methodologies for the determination of ticagrelor
Hajnal Kelemen1, Gabriel Hancu1, Lajos Attila Papp1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy Science and Technology from Târgu Mureș, Romania.
Biomedical Chromatography : BMC
|March 6, 2019
Summary
This review summarizes analytical methods for ticagrelor, a P2Y12 receptor antagonist used in acute coronary syndrome. It covers techniques like spectrophotometry and chromatography for ticagrelor determination in various samples.
Area of Science:
- Analytical Chemistry
- Pharmacology
- Clinical Chemistry
Background:
- Ticagrelor is a vital P2Y12 receptor antagonist for managing acute coronary syndromes.
- Its clinical efficacy necessitates reliable quantification in pharmaceutical and biological matrices.
Purpose of the Study:
- To systematically review and survey analytical techniques for ticagrelor determination.
- To cover methods developed since ticagrelor's therapeutic introduction.
Main Methods:
- Literature search for analytical methods including spectrophotometry, HPLC-UV, and LC-MS/MS.
- Analysis of methods for pharmaceutical and biological sample matrices.
Main Results:
- Multiple analytical methods exist for ticagrelor quantification.
- Spectrophotometry, HPLC-UV, and LC-MS/MS are commonly employed.
Conclusions:
- A range of validated analytical techniques are available for ticagrelor monitoring.
- Continued development of sensitive and specific methods is crucial for therapeutic drug monitoring.
Related Concept Videos
01:21Development of Analytical Methods
2.2K
An analytical methodology can be divided into four sequential steps: technique, method, procedure, and protocol. A technique is a scientific principle that rationalizes a specific phenomenon through chemical measurements. Adapting a technique for analyzing a sample of interest is termed a method. The procedure outlines the directions for performing the analysis via an analytical method. The protocol is the detailed guidelines on the procedure, which should be strictly followed to obtain the...
2.2K
01:09Analyte Adsorption and Distribution
2.8K
In certain chromatographic separations, solutes transfer between the mobile phase and the stationary phase via sorption, which typically refers to the process of adsorption. For many chromatographic systems, the sorption process often depends on the polarity of the compounds—an expression of the overall dipole moment within the molecule. During the separation process, there is competition between the solute and solvent for adsorption to the stationary phase. Highly polar compounds and...
2.8K
01:23Jung's Analytical Theory
1.1K
Carl Jung, a Swiss psychiatrist and former follower of Freud, eventually broke away from Freud's ideas to create his framework, analytical psychology. This approach emphasizes achieving a balance between the conscious and unconscious aspects of the mind and reconciling various experiences within an individual's personality. Jung believed that this process, which typically unfolds in the latter part of life, involves an ongoing journey of recognizing and incorporating unconscious...
1.1K
01:20Graphical and Analytic Representation of Sinusoids
965
Analyzing two sinusoidal voltages with equal amplitude and period but different phases on an oscilloscope, an instrument used to display and analyze waveforms, involves a three-step process.
The first step is measuring the peak-to-peak value, which is twice the amplitude of the sinusoid. This provides information about the maximum voltage swing of the waveform.
Secondly, the period and angular frequency are determined. The period is the time taken for one complete cycle of the waveform, while...
The first step is measuring the peak-to-peak value, which is twice the amplitude of the sinusoid. This provides information about the maximum voltage swing of the waveform.
Secondly, the period and angular frequency are determined. The period is the time taken for one complete cycle of the waveform, while...
965
01:16Response Surface Methodology
640
Response Surface Methodology (RSM) is a collection of statistical and mathematical techniques used to develop, improve, and optimize processes. It is particularly valuable when many input variables or factors potentially influence a response variable.
The process of RSM involves several key steps:
The process of RSM involves several key steps:
640
02:53Determining Order of Reaction
61.9K
Rate laws describe the relationship between the rate of a chemical reaction and the concentration of its reactants. In a rate law, the rate constant k and the reaction orders are determined experimentally by observing how the rate of reaction changes as the concentrations of the reactants are changed. A common experimental approach to the determination of rate laws is the method of initial rates. This method involves measuring reaction rates for multiple experimental trials carried out using...
61.9K