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Updated: Jan 28, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
A Mouse Model to Study Reparative Dentinogenesis
R C Babb1, D Chandrasekaran1, L K Zaugg1
1Department of Craniofacial Development and Stem Cell Biology, Centre for Craniofacial and Regenerative Biology (CCRB), Dental Institute, King's College London, London, UK.
Abstract:
Different animal models have been introduced recently to study the process of reparative dentinogenesis in response to injury-induced pulp exposure. Using a mouse model is advantageous over other animal models since mice can be genetically manipulated to examine specific cellular pathways and lineage trace the progeny of a single cell. However, enabling a standardized molar damage in mice is demanding due to the small size of the teeth compared to the available dental instruments. Here we describe a reproducible and reliable in vivo model that allows us to study dentinogenesis in the first maxillary mouse molar.
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