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Updated: Jan 28, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
Published on: August 14, 2019
Diffusion weighted imaging of esthesioneuroblastoma: Differentiation from other sinonasal masses
Aaron C Miracle1, Ivan H El-Sayed2,3, Christine M Glastonbury4
1Department of Radiology, Kaiser Permanente Oakland Medical Center, Oakland, California.
Background:
Differentiating esthesioneuroblastoma (ENB) from other sinonasal tumors is difficult by MRI. We tested whether diffusion weighted imaging (DWI) could distinguish ENB from other sinonasal tumors.
Methods:
Hundred forty-six patients underwent sinonasal MRI, 75 with technically successful DWI. Pathology: 18 ENB (24%), 34 (45%) other malignant tumors, and 23 (31%) benign lesions. Apparent diffusion coefficients (ADCs) were calculated.
Results:
Average ADC and normalized ADC of ENB (1.22 × 10-3 ± 0.28 mm2 /s and 1.55 ± 0.36, respectively) were higher than other malignancies (0.98 × 10-3 ± 0.18 mm2 /s and 1.31 ± 0.29, P = .002 and P = .034) and lower than benign disease (1.92 × 10-3 ± 0.33 mm2 /s and 2.44 ± 0.50, P < .0001). ADC differentiated ENB from benign disease with 91% sensitivity and 83% specificity. An ADC cutoff of 1.1 × 10-3 mm2 /s differentiated other malignancies from ENB with 72% sensitivity and 85% specificity.
Conclusions:
DWI is useful in distinguishing ENB from other sinonasal disease.
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