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Updated: Jan 28, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
[Association between depressive symptoms and metabolic control in patients with type 2 diabetes mellitus: a
María José Valenzuela1, Bárbara Münzenmayer2, Tomás Osorio2
1Departamento de Medicina Interna, Escuela de Medicina, Universidad de Valparaíso, Viña del Mar, Chile.
Background:
Patients with diabetes mellitus show a higher risk of developing depressive symptoms when compared to healthy people, hampering the management and prognosis of both diseases. However, national studies on the topic are scarce.
Aim:
To study the frequency and severity of depressive symptoms in patients with type 2 diabetes.
Material And Methods:
Beck Depression Inventory-IA and Morisky Green Levine scale were administered to diabetic patients under control at a primary care center. Pharmacological compliance was evaluated using glycosylated hemoglobin levels obtained from their clinical records.
Results:
We included 323 patients aged 64 ± 12 years (49% women). The frequency of depressive symptoms was 34.7%. Compared with their counterparts without depressive symptoms, patients with depression showed higher glycosylated hemoglobin levels (7.2 ± 1.7 and 6.7 ± 1.3% respectively), a higher frequency of non-compliance with treatment (63 and 43% respectively) and a higher frequency of metabolic decompensation (38 and 23% respectively). Depressive symptomatology was more common among women.
Conclusions:
Patients with type 2 diabetes mellitus and depressive symptoms exhibit a poorer treatment compliance and worse metabolic control as compared to their non-depressive counterparts.
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