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Related Concept Videos

The Mitotic Spindle02:27

The Mitotic Spindle

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The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
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Spindle Assembly02:50

Spindle Assembly

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Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
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The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

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The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
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What are Cells?01:07

What are Cells?

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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
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Concentration Cells02:41

Concentration Cells

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A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
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What is Cell Signaling?02:03

What is Cell Signaling?

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

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Updates in spindle cell/pleomorphic lipomas.

Benjamin J Van Treeck1, Karen J Fritchie1

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA.

Seminars in Diagnostic Pathology
|March 10, 2019
PubMed
Summary
This summary is machine-generated.

Spindle cell/pleomorphic lipomas are benign tumors with specific cellular and collagen features. This review details their characteristics, differential diagnoses, and diagnostic approaches for challenging cases.

Keywords:
CD34Pleomorphic lipomaRB1Spindle cell lipoma

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Area of Science:

  • Surgical pathology
  • Oncology
  • Dermatopathology

Background:

  • Spindle cell/pleomorphic lipomas are benign lipomatous neoplasms.
  • They are characterized by mature adipose tissue, bland spindled cells, and ropy collagen.
  • Loss of the RB1 gene is a key feature.

Purpose of the Study:

  • To review the clinicopathologic features and morphologic spectrum of spindle cell/pleomorphic lipoma.
  • To discuss an updated differential diagnosis for these tumors.
  • To provide a practical diagnostic strategy for atypical presentations.

Main Methods:

  • Literature review of clinicopathologic features.
  • Analysis of morphologic spectrum.
  • Discussion of differential diagnoses and diagnostic strategies.

Main Results:

  • Spindle cell/pleomorphic lipomas exhibit a defined set of histopathologic features.
  • An updated differential diagnosis is presented, considering various benign and malignant entities.
  • A diagnostic strategy is outlined for accurate identification, especially in atypical cases.

Conclusions:

  • Accurate diagnosis of spindle cell/pleomorphic lipoma relies on recognizing characteristic features.
  • Understanding the differential diagnosis is crucial for appropriate patient management.
  • A systematic approach aids in diagnosing challenging cases with atypical presentations.