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Association Between Nitrite and Nitrate Intake and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis
Fei-Xiong Zhang1, Yu Miao1, Ji-Gang Ruan1
1Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China (mainland).
High nitrite intake increases gastric cancer risk, while nitrate intake may reduce it. This meta-analysis clarifies the complex relationship between these dietary compounds and gastric cancer risk.
Area of Science:
- Nutrition Science
- Gastroenterology
- Cancer Epidemiology
Background:
- Inconsistent associations between nitrite/nitrate intake and gastric cancer risk.
- Need for a comprehensive meta-analysis to clarify these relationships.
Purpose of the Study:
- To evaluate the correlation between nitrite and nitrate intake and gastric cancer risk.
- To synthesize evidence from observational studies.
Main Methods:
- Meta-analysis of 24 observational studies (18 case-control, 6 cohort).
- Searched PubMed, EMBASE, and Cochrane Library up to November 2018.
- Pooled effect estimates using a random-effects model.
Main Results:
- Higher nitrite intake associated with increased gastric cancer risk (OR 1.27).
- Higher nitrate intake associated with reduced gastric cancer risk (OR 0.81).
- Associations varied based on study characteristics.
Conclusions:
- Nitrite intake linked to elevated gastric cancer risk.
- Nitrate intake linked to decreased gastric cancer risk.
- Dietary management of nitrite and nitrate may influence gastric cancer prevention.
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