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Updated: Jan 28, 2026

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
Published on: March 29, 2018
Titanium Mesh Grafting Combined with Recombinant Human Bone Morphogenetic Protein 2 for Alveolar Reconstruction
Alan S Herford1, Isaac Lowe1, Paul Jung1
1Department of Oral and Maxillofacial Surgery, Loma Linda University School of Dentistry, 11092 Anderson Street, Loma Linda, CA 92350, USA.
Abstract:
There are several methods of regenerating the maxillary and mandibular ridge to achieve orthoalveolar form with bone grafting procedures, including block onlay grafting and guided bone regeneration. Traditionally, guided bone regeneration has focused on creating a space for bone regeneration to occur. The use of a formed titanium mesh to regenerate alveolar defects was popularized in the 1980s. With the advent of other adjuncts, such as resorbable membranes, and growth factors, such as recombinant human bone morphogenetic protein 2, the predictability of the procedure has increased and a wide variety of defects can be restored using this technology.
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