Related Experiment Video
Updated: Jan 28, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
[Gerontological evaluation benefits for very older people with cardiovascular disease]
Amaury Broussier1, Lucie Valembois2, Carmelo Lafuente-Lafuente3
1AP-HP, hôpital Henri-Mondor/Émile-Roux, department of geriatrics, 94450 Limeil-Brévannes, France.
Abstract:
The multidimensional, multiprofessional gerontological evaluation helps identify geriatric syndromes and situations of fragility. This is a first step to establish a plan of care and assistance, to reduce the risk of falls, hospitalization, entry into institutions and to prevent a decline in independence. Older people with cardiovascular disease such as heart failure are at very high risk of repeated hospitalizations, with an average of 45% of patients re-hospitalized in the year following all-cause hospitalization. In the context of heart failure, frailty is an independent risk factor for mortality within 30 days of leaving hospital. Screening for frailty before transcatheter aortic valve implantation (TAVI) or interventional rhythmic procedure is a determining factor in decision-making for benefit in terms of survival and quality of life in elderly patients. Vascular diseases by their cerebral complications represent the first cause of mortality and the first cause of loss of functional independence in the subjects of more than 65 years. Vascular disease is a risk factor for cognitive impairment in the elderly.
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